• Product Details

Keywords

• Estriol
• cas 50-27-1
• TRIDESTRIN

Quick Details

• ProName:Estriol cas no 50-27-1.1
• CasNo:50-27-1
• Molecular Formula:C18H24O3
• Appearance:white crystalline powder
• Application:A metabolite of Estradiol. An estrogen...
• DeliveryTime:5days
• PackAge:in foil bag or customized
• Port:Tianjin xingang
• ProductionCapacity:10 Kilogram/Week
• Purity:99%
• Storage:It should be sealed upon shading for s...
• Transportation:shipping by courier or by sea
• LimitNum:10 Gram
• Related Substances:99%
• Residue on Ignition:less than 0.5%
• Heavy Metal:less than 0.5%
• Valid Period:1 year

Superiority

 

estriol chemical properties

mp	280-282 °c(lit.)
refractive index	58 ° (c=0.4, dioxane)
storage temp.	-20°c freezer
merck	3707
cas database reference	50-27-1(cas database reference)
nist chemistry reference	estriol(50-27-1)

 

 

Details

Estriol Usage And Synthesis

Natural hormone	Estriol belongs to natural hormone and is the metabolite of estradiol in vivo. It is mainly presented in the urine. Estrogen has a relative small activity with the oral activity being 6 times as high as estrone but being weaker than estradiol with non-carcinogenic effects.  Figure 1 is the formula of estriol
Pharmacokinetics	It can be absorbed from the gastrointestinal tract and skin but is susceptible to damage upon oral administration and is therefore mainly subject to intramuscular injection and topical usage. It is metabolized in the body to less-active estrone and estriol and can be inactivated when being combined with glucuronic acid and sulfuric acid and further excreted in urine.

Storage	It should be sealed upon shading for storage.
Chemical Properties	It is white crystalline powder with the M.p. being 283 ℃, relative density being 1.27, and the specific rotation being [α] 25D + 34.4°(pyridine) and 25D + 58°± 5°(4%, dioxane). Its ethanol solution has maximum absorption at the wavelength of 280 nm. The crystal is insoluble in water, slightly soluble in ethanol (1: 500), diethyl ether, chloroform, dioxane and vegetable oil and easily soluble in pyridine and alkali hydroxide solution.
Application	It belongs to estrogen drug. It can be used for treating leukopenia, various kinds of menopathy, senile vaginitis, and menopausal syndrome. You may also get temporary breast swelling and lumps, menstrual cycle disorders with self-recovery after stopping the drug for about 1 month. Patients of breast hyperplasia, breast lumps, and cancer potentially being related to female hormone-related cancer, aplastic anemia and liver disease patients should be disabled.
Production method	Take estrone as raw material; go through acetylation, epoxidation, and reduction to obtain the estriol products.  Estrone [acetylation] → [16, 17- epoxidation] → [rearrangement] → [Restore] → [hydrolysis] → finished product of estriol.  Estrone acetate successively goes through followed enolization, acetylation, epoxidation and reduction to obtain it.
Chemical Properties	White Crystalline Powder
Usage	17b-estradiol metabolite, primary estrogen in urine
Usage	A metabolite of Estradiol. An estrogenic metabolite considerably less potent than the hormone Estradiol

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